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@pirl-unc Personalized Immunotherapy Research Lab @ UNC

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    103 repositories

    • DoesExactoWorkYet

      Public
      Simple end-to-end test of Exacto
      Python
      •
      Apache License 2.0
      •0•0•0•0•Updated Aug 10, 2026Aug 10, 2026

    • io-resistance-genie

      Public
      [WIP / experiment] Living literature review of resistance to immune checkpoint inhibitors
      experimentwipimmunotherapy
      experimentwipimmunotherapyliterature-reviewliving-reviewanti-pd1
      Python
      •0•2•1•0•Updated Aug 8, 2026Aug 8, 2026

    • raft-ui

      Public
      RAFT web interface for generating manifests and configuration files.
      HTML
      •0•0•0•0•Updated Aug 8, 2026Aug 8, 2026

    • nexus

      Public
      A command-line streamliner for Nextflow bioinformatics pipelines.
      nextflowbioinformatics-pipelines
      nextflowbioinformatics-pipelines
      Nextflow
      •
      Apache License 2.0
      •1•2•0•0•Updated Aug 6, 2026Aug 6, 2026

    • trufflepig

      Public
      Step-by-step RNA tumor analysis driven by pirlygenes gene sets — subsumes pirlygenes.analyze as many composable sub-commands with serializable intermediate stat…
      Python
      •
      Apache License 2.0
      •0•0•62•3•Updated Aug 4, 2026Aug 4, 2026

    • pirlygenes

      Public
      Gene sets used for cancer immunotherapy expression analysis
      Python
      •
      Apache License 2.0
      •1•1•11•1•Updated Aug 4, 2026Aug 4, 2026

    • oncoref

      Public
      Curated cancer reference data: ontology, TMB, incidence/mortality, and expression. Bottom-of-stack for the openvax/PIRL libraries.
      Python
      •
      Apache License 2.0
      •0•3•8•0•Updated Aug 3, 2026Aug 3, 2026

    • tcrsift

      Public
      Python
      •
      Apache License 2.0
      •0•0•0•0•Updated Jul 29, 2026Jul 29, 2026

    • alcohol-immunotherapy

      Public
      Data and code for "Alcohol use reduces the efficacy of anti-PD1 immunotherapy by disrupting anti-tumor immunity"
      0•0•0•0•Updated Jul 28, 2026Jul 28, 2026

    • tsarina

      Public
      Tumor Specific Antigen discovery: personalized cancer immunotherapy targets from curated shared antigen data
      Python
      •
      Apache License 2.0
      •0•3•5•0•Updated Jul 24, 2026Jul 24, 2026

    • mhcgnomes

      Public
      Parsing MHC nomenclature in the wild
      Python
      •
      Apache License 2.0
      •5•21•3•3•Updated Jul 22, 2026Jul 22, 2026

    • spearmint

      Public
      Accompanying Repository to SPEARMINT paper.
      Python
      •
      MIT License
      •2•0•0•0•Updated Jul 1, 2026Jul 1, 2026

    • pdockq-slurm-workflow

      Public
      Python
      •0•0•0•0•Updated Jun 19, 2026Jun 19, 2026

    • aggrescan3d-slurm-workflow

      Public
      Python
      •0•0•0•0•Updated Jun 19, 2026Jun 19, 2026

    • hitlist

      Public
      Curated mass spectrometry evidence for MHC ligand data from IEDB and CEDAR
      Python
      •
      Apache License 2.0
      •0•3•29•0•Updated Jun 19, 2026Jun 19, 2026

    • mhcseqs

      Public
      MHC sequences
      Python
      •
      Apache License 2.0
      •0•2•4•0•Updated Jun 10, 2026Jun 10, 2026

    • vstol

      Public
      Variant Standardization, Tabulation, and Operations Library
      variant-annotationvariant-filtrationvariant-analysis
      variant-annotationvariant-filtrationvariant-analysis
      Python
      •0•4•0•0•Updated Jun 4, 2026Jun 4, 2026

    • exacto

      Public
      Long-read toolkit for mutant proteoform prediction - somatic/germline DNA and RNA variant calling, integration, and translation
      long-read-sequencingneoantigensmutant-proteoforms
      long-read-sequencingneoantigensmutant-proteoformsvariant-isoformsprimary-structures
      Rust
      •
      Apache License 2.0
      •0•3•0•0•Updated May 27, 2026May 27, 2026

    • runplz

      Public
      Tiny Modal-shaped job harness
      Python
      •
      Apache License 2.0
      •0•3•2•0•Updated May 13, 2026May 13, 2026

    • presto

      Public
      All of T-cell:pMHC prediction in one model
      Python
      •
      Apache License 2.0
      •0•1•0•0•Updated May 13, 2026May 13, 2026

    • io-shieldbreak

      Public
      Python
      •0•0•0•0•Updated Apr 27, 2026Apr 27, 2026

    • vmwhere

      Public
      Python
      •
      Apache License 2.0
      •0•0•0•0•Updated Apr 14, 2026Apr 14, 2026

    • squid-tui

      Public
      Squid-TUI (Slurm QUeue Interactive Dashboard): Terminal UI (TUI) for organizing, filtering, and managing SLURM jobs.
      Python
      •0•0•0•0•Updated Apr 13, 2026Apr 13, 2026

    • golfy

      Public
      Heuristic solver for pooled peptide experiment design
      Jupyter Notebook
      •
      Apache License 2.0
      •1•0•1•0•Updated Apr 8, 2026Apr 8, 2026

    • weirdo

      Public
      Metrics of immunological foreignness for candidate T-cell epitopes
      Jupyter Notebook
      •
      Apache License 2.0
      •0•0•0•0•Updated Apr 7, 2026Apr 7, 2026

    • perseo

      Public
      Personalized cancer immunotherapy target selection from curated shared antigen data
      Python
      •
      Apache License 2.0
      •0•0•0•0•Updated Mar 28, 2026Mar 28, 2026

    • singlecell_decontamination

      Public
      Docker files for images containing seurat + scCDC and seurat + decontx ( celda )
      Dockerfile
      •
      GNU General Public License v3.0
      •0•0•0•0•Updated Jan 28, 2026Jan 28, 2026

    • hf-tcr

      Public
      HuggingFace Scaffolding for EZ TCR Generation and Evaluation
      Python
      •
      Apache License 2.0
      •0•1•0•0•Updated Jan 17, 2026Jan 17, 2026

    • TCRpMHCdataset

      Public
      Python Class for Handling Many-to-Many Nature of TCR::pMHC Data
      Python
      •
      Apache License 2.0
      •1•1•0•0•Updated Jan 12, 2026Jan 12, 2026

    • pirl-blog-notebooks

      Public
      Jupyter notebooks accompanying PIRL Blog posts
      Jupyter Notebook
      •
      Apache License 2.0
      •0•0•0•0•Updated Dec 5, 2025Dec 5, 2025
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