Python package for Genome-Wide Association Studies (GWAS). Implements GLM, MLM, FarmCPU, and BLINK with support for VCF, PLINK, HapMap, and CSV genotype formats.
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Updated
Jul 9, 2026 - Python
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genome-wide-association-study
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End-to-end TWAS pipeline for Alzheimer's disease integrating Kunkle et al. (2019) GWAS summary statistics with GTEx v8 MASHR brain eQTL models to identify causal genes via cross-tissue omnibus regression and functional pathway over-representation analysis.
gwas gene-expression gtex alzheimers-disease eqtl summary-statistics neurogenomics twas genome-wide-association-study brain-tissue neurodegenerative-disease transcriptome-wide-association-study spredixcan smultixcan metaxcan cross-tissue-analysis mashr predictdb snp-harmonization
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Jun 9, 2026 - Python
Using Mendelian Randomization to decipher the prodrome of Amyotrophic Lateral Sclerosis and Parkinson's Disease
linkage-disequilibrium parkinsons-disease instrumental-variable mendelian-randomization amyotrophic-lateral-sclerosis type-2-diabetes genome-wide-association-study neurodegenerative-disease single-nucleotide-polymorphism
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Dec 8, 2025 - Jupyter Notebook
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