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CDK11 Study — Repository

Code and analysis scripts accompanying the following preprint:

Julian LA, Crozier L, Lukow D, et al. On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions. bioRxiv. 2025;2025.08.03.668359. Published 2025 Aug 3. doi:10.1101/2025.08.03.668359

Contents

  • Intron retention — Figure 2
  • ChIP-seq analysis — Figure S4
  • Biomarker analysis — Figure 4
  • Network analysis
  • Figure code — scripts for manuscript figures

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Scripts used in the CDK11 project including RNA-seq, intron-retention, phosphoproteomics, and Depmap data analysis.

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