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								<h1 class="site-title">Developmental Cancer Genomics</h1>
								<small class="site-description">Taking apart childhood cancer <tt>bit</tt> by <tt>bit</tt></small>
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					<small>Taking apart childhood cancer <tt>bit</tt> by <tt>bit</tt></small>
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						<p>We are a <a href="people.html">team</a> of computational and experimental biologists at <a href="https://science.ccri.at/">St. Anna Children's Cancer Research Institute (CCRI)</a>. It is our goal to understand developmental processes in cancer biology by employing an integrative approach that combines stem cell biology with functional genomics.</p>
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								<h4>We trace (aberrant) changes in cells during development.</h4>
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									<div>Background: Hematopoiesis, immunity, and cancer</div>
									<span><a href="https://doi.org/10.1016/j.stem.2016.10.019" title="DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation">Cell Stem Cell 2016</a>;</span>
									<span><a href="https://doi.org/10.1126/science.aaf4238" title="Specification of tissue-resident macrophages during organogenesis">Science 2016</a>;</span>
									<span><a href="https://doi.org/10.1158/2159-8290.CD-19-0138" title="Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis">Cancer Discov. 2019</a></span>
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								<h4>We map regulatory networks that shape cell identity.</h4>
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									<div>Background: Stem cell transcription factors</div>
									<span><a href="https://doi.org/10.1016/j.stem.2012.08.002" title="Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells">Cell Stem Cell 2012</a>, <a href="https://doi.org/10.1016/j.stem.2013.04.023" title="Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog">2013</a>;</span>
									<span><a href="https://doi.org/10.7554/eLife.27746" title="Distinct SoxB1 networks are required for naïve and primed pluripotency">eLife 2017</a>;</span>
									<span><a href="https://doi.org/10.15252/embj.201695476" title="Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation">EMBO J. 2018</a></span>
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								<h4>We develop tools that connect pieces of data into knowledge.</h4>
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									<div>Background: Wet- and dry-lab tools and resources</div>
									<span><a href="https://doi.org/10.1038/nmeth.1809" title="GeneProf: analysis of high-throughput sequencing experiments">Nat. Methods 2012</a>;</span>
									<span><a href="https://doi.org/10.1038/nbt.3605" title="Quantitative comparison of DNA methylation assays for biomarker development and clinical applications">Nat. Biotechnol. 2016</a>;</span>
									<span><a href="https://doi.org/10.1016/j.stem.2018.06.014" title="Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells">Cell Stem Cell 2018</a></span>
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								<h4 class="ybg">Our research currently focuses on understanding and modulating the earliest effects of cancer-linked mutations on development, tumorigenicity, and plasticity in embryonal tumors and other childhood cancers.</h4>
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									To this end, we use stem cell organoids and other experimental models and genomics technologies.
									<span><a href="https://doi.org/10.1038/s42003-025-08730-4" title="A stem cell differentiation model reveals two alternative fates in CBFA2T3::GLIS2-driven acute megakaryoblastic leukemia initiation">Commun. Biol. 2025</a></span>;
									<span><a href="https://doi.org/10.1038/s41467-024-47945-7" title="A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations">Nat. Commun. 2024a</a></span>;
									<span><a href="https://doi.org/10.1038/s41467-024-45802-1" title="Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation">Nat. Commun. 2024b</a></span>;
									<span><a href="https://doi.org/10.1093/nar/gkag124" title="Directing stem cell differentiation by chromatin state approximation">Nucleic Acids Res. 2026</a></span>
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							<i class="fa fa-newspaper-o"></i> Check out our latest pre-print: <span><a href="https://doi.org/10.1101/2025.04.24.650451">Montano, Mueller, et al.</a></span></a>
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										<h3 class="widget-title">Where to find us:</h3>
										<strong>Developmental Cancer Genomics</strong>
										<div>Florian Halbritter Lab</div>
										<address>St. Anna Children's Cancer Research Institute (CCRI), Zimmermannplatz 10, 1090 Vienna, Austria</address>
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