16 and 10 byte keys use different constants, as [described in the Salsa20 paper](https://cr.yp.to/snuffle/salsafamily-20071225.pdf): > The diagonal constants are the same for every block, every nonce, and every > 32-byte key. As an extra (non-recommended) option, Salsa20 can use a 16-byte > key, repeated to form a 32-byte key; in this case the diagonal constants change to > 0x61707865, 0x3120646e, 0x79622d36, 0x6b206574. Salsa20 can also use a 10- > byte key, zero-padded to form a 16-byte key; in this case the diagonal constants > change to 0x61707865, 0x3120646e, 0x79622d30, 0x6b206574. RustCrypto only supports the 32-byte key: https://github.com/RustCrypto/stream-ciphers/blob/07ee501ac9067abe0679a596aa771a575baec68e/salsa20/src/lib.rs#L120-L121 So it's not possible to "extend" the key without changing the constant.