diff --git a/src/env.cc b/src/env.cc
index f618fca2e2d157..141991a9a5736a 100644
--- a/src/env.cc
+++ b/src/env.cc
@@ -1411,9 +1411,19 @@ void Environment::RunAndClearInterrupts() {
   }
 }
 
+bool Environment::HasNativeImmediates() const {
+  return native_immediates_.size() > 0 ||
+         native_immediates_threadsafe_.size() > 0 ||
+         native_immediates_interrupts_.size() > 0;
+}
+
 void Environment::RunAndClearNativeImmediates(bool only_refed) {
   TRACE_EVENT0(TRACING_CATEGORY_NODE1(environment),
                "RunAndClearNativeImmediates");
+  if (!HasNativeImmediates()) {
+    return;
+  }
+
   HandleScope handle_scope(isolate_);
   // In case the Isolate is no longer accessible just use an empty Local. This
   // is not an issue for InternalCallbackScope as this case is already handled
@@ -1586,6 +1596,9 @@ void Environment::CheckImmediate(uv_check_t* handle) {
   Environment* env = Environment::from_immediate_check_handle(handle);
   TRACE_EVENT0(TRACING_CATEGORY_NODE1(environment), "CheckImmediate");
 
+  if (env->immediate_info()->count() == 0 && !env->HasNativeImmediates())
+    return;
+
   HandleScope scope(env->isolate());
   Context::Scope context_scope(env->context());
 
diff --git a/src/env.h b/src/env.h
index 5fabc366c6e68b..2e644983ea1d0a 100644
--- a/src/env.h
+++ b/src/env.h
@@ -1034,6 +1034,7 @@ class Environment final : public MemoryRetainer {
 
   void RunAndClearNativeImmediates(bool only_refed = false);
   void RunAndClearInterrupts();
+  bool HasNativeImmediates() const;
 
   uv_buf_t allocate_managed_buffer(const size_t suggested_size);
   std::unique_ptr<v8::BackingStore> release_managed_buffer(const uv_buf_t& buf);
diff --git a/test/cctest/test_environment.cc b/test/cctest/test_environment.cc
index ee9052a1dad4e4..59c71835499e41 100644
--- a/test/cctest/test_environment.cc
+++ b/test/cctest/test_environment.cc
@@ -401,6 +401,69 @@ TEST_F(EnvironmentTest, SetImmediateCleanup) {
   EXPECT_EQ(called_unref, 0);
 }
 
+TEST_F(EnvironmentTest, RunAndClearNativeImmediatesSkipsEmptyScope) {
+  const v8::HandleScope handle_scope(isolate_);
+  const Argv argv;
+  Env env{handle_scope, argv};
+  v8::Local<v8::Context> context = env.context();
+
+  using IntVec = std::vector<int>;
+  IntVec callback_calls;
+  v8::Local<v8::Function> must_call =
+      v8::Function::New(
+          context,
+          [](const v8::FunctionCallbackInfo<v8::Value>& info) {
+            IntVec* callback_calls =
+                static_cast<IntVec*>(info.Data().As<v8::External>()->Value(
+                    v8::kExternalPointerTypeTagDefault));
+            callback_calls->push_back(info[0].As<v8::Int32>()->Value());
+          },
+          v8::External::New(isolate_,
+                            static_cast<void*>(&callback_calls),
+                            v8::kExternalPointerTypeTagDefault))
+          .ToLocalChecked();
+  context->Global()
+      ->Set(context,
+            v8::String::NewFromUtf8Literal(isolate_, "mustCall"),
+            must_call)
+      .Check();
+
+  v8::Local<v8::Function> eval_in_env =
+      node::LoadEnvironment(*env, "return eval;")
+          .ToLocalChecked()
+          .As<v8::Function>();
+
+  v8::Local<v8::Value> queue_microtask = v8::String::NewFromUtf8Literal(
+      isolate_, "Promise.resolve().then(() => mustCall(1));");
+  eval_in_env->Call(context, v8::Null(isolate_), 1, &queue_microtask)
+      .ToLocalChecked();
+  EXPECT_TRUE(callback_calls.empty());
+  (*env)->RunAndClearNativeImmediates();
+  EXPECT_TRUE(callback_calls.empty());
+
+  context->GetMicrotaskQueue()->PerformCheckpoint(isolate_);
+  EXPECT_EQ(callback_calls, (IntVec{1}));
+  callback_calls.clear();
+
+  queue_microtask = v8::String::NewFromUtf8Literal(
+      isolate_, "Promise.resolve().then(() => mustCall(2));");
+  eval_in_env->Call(context, v8::Null(isolate_), 1, &queue_microtask)
+      .ToLocalChecked();
+  EXPECT_TRUE(callback_calls.empty());
+
+  bool native_immediate_called = false;
+  (*env)->SetImmediate(
+      [&](node::Environment* env_arg) {
+        EXPECT_EQ(env_arg, *env);
+        native_immediate_called = true;
+      },
+      node::CallbackFlags::kRefed);
+
+  (*env)->RunAndClearNativeImmediates();
+  EXPECT_TRUE(native_immediate_called);
+  EXPECT_EQ(callback_calls, (IntVec{2}));
+}
+
 static char hello[] = "hello";
 
 TEST_F(EnvironmentTest, BufferWithFreeCallbackIsDetached) {