diff --git a/meson.build b/meson.build
index dce5c68ef..6d1f52048 100644
--- a/meson.build
+++ b/meson.build
@@ -252,7 +252,7 @@ else
   conf.set('fallthrough', 'do {} while (0) /* fallthrough */')
 endif
 
-if openssl_dep.found()
+if openssl_dep.found() and meson.can_run_host_binaries()
   if openssl_dep.type_name() != 'internal'
     # Check for a bug in the EVP_PKEY_CTX_add1_hkdf_info implementation
     res = cc.run(