-When using Configuration Manager, the best path for management of security policy is using [Configuration Manager tenant attach](/mem/configmgr/tenant-attach/endpoint-security-get-started). In some environments it may be desired to use Security Management for Microsoft Defender for Endpoint. When using Security Management for Microsoft Defender for Endpoint with Configuration Manager, endpoint security policy should be isolated to a single control plane. Controlling policy through both channels will create the opportunity for conflicts and undesired results.
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