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memdocs/configmgr/protect/deploy-use/defender-advanced-threat-protection.md

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title: Microsoft Defender for Endpoint
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titleSuffix: Configuration Manager
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description: Learn how to manage and monitor Microsoft Defender for Endpoint, a new service that helps enterprises respond to advanced attacks.
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ms.date: 10/05/2021
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ms.date: 12/02/2021
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ms.prod: configuration-manager
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ms.technology: configmgr-protect
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ms.topic: conceptual
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- Windows Server 2012 R2
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- Windows Server 2016
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> [!Note]
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> Currently, the [modern, unified Microsoft Defender for Endpoint for Windows Server 2012 R2 & 2016](https://techcommunity.microsoft.com/t5/microsoft-defender-for-endpoint/defending-windows-server-2012-r2-and-2016/bc-p/2904464) is in public preview. Configuration Manager version 2107 with the update rollup supports configuration using Endpoint Protection policies, including those policies created in the Microsoft Endpoint Manager admin center using tenant attach. For more information on how to deploy the preview, see [Server migration scenarios](/microsoft-365/security/defender-endpoint/server-migration).
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When you onboard devices to Microsoft Defender for Endpoint with Configuration Manager, you deploy the Defender policy to a target collection or multiple collections. Sometimes the target collection contains devices running any number of the supported operating systems. The instructions for onboarding these devices vary based on if you're targeting a collection containing devices with operating systems that are only up-level or if the collection also includes down-level clients.
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- If your target collection contains both up-level and down-level devices, then use the instructions to [onboard devices running any supported operating system](#bkmk_any_os) (recommended).

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